EPAS1 and cancer: Evidences of the above predictions were found in cancer-related mutations located in the ARNT PAS-A FG loop (in particular, D238N) and in the HIF-2α faced strands (R247H, D258N, Fig 8B and S4 Table), as well as in the short α-helical region of the HIF-2α C-terminal linker (S355F, T359A, Fig 8A and S4 Table).