Importantly, the elevated TCT→TAT error rate we observed with the D275A/E277A mutant was not statistically different from those measured with the S459F and S461P Pol ε cancer mutants previously (Shinbrot et al., 2014; Shlien et al., 2015), suggesting a common mechanism of mutagenesis for these hotspot mutations. The gene discussed is EPX; the disease is cancer.