EPX and endometrial cancer: These hotspots are seen in Pol ε tumors from patients with bMMRD (Shlien et al., 2015), colorectal and endometrial cancer (Alexandrov and Stratton, 2014; Cancer Genome Atlas Network, 2012; Kandoth et al., 2013; Shinbrot et al., 2014), as well as in the Pol ε-P286R HCC2998 cells (Figure 2—figure supplement 1, data extracted from [Abaan et al., 2013]).