2012). Tubular injury in sepsis is subtle and focal, despite significant renal dysfunction (Langenberg et al. 2008; Lerolle et al. 2010). Changes in renal function in sepsis are likely to be functional, rather than due to structural injury or hemodynamic insufficiency, with reductions in renal tubular epithelial ion channel or transporter expression in response to inflammatory stimuli, including IL‐1β (Schmidt et al. 2007). The gene discussed is IL1B; the disease is Sepsis.