P2RX7 and Sepsis: 2014). The notion that NLRP3 inhibition may be beneficial in sepsis‐induced AKI was demonstrated by caspase‐1 deficiency in a lipopolysaccharide (LPS) model of endotoxaemia (Wang et al. 2005). Similarly, P2X7 knockout (KO) mice subjected to cecal ligation and puncture have an attenuated inflammatory response and reduced lung injury compared with wild‐type mice (Santana et al. 2015).