P2RX7 and Sepsis: 2015; Savio et al. 2016, 2017). However, others have demonstrated increased mortality with E. coli urosepsis in P2X7‐deficient mice (Greve et al. 2017). However, the role of a selective P2X7 receptor inhibitor has not been evaluated in a clinically relevant model of sepsis in which treatment is administered following the onset of sepsis. We demonstrate that P2X7 inhibition with A‐438079 after the onset of sepsis reduced renal IL‐1β early expression and abrogated the rise in serum creatinine concentration at 24 h.