Notably, comprehensive studies of patients at increased risk for dehydration (e.g., T2D individuals > 75 years old and/or receiving concomitant diuretic therapy) are currently scarce, so careful weighing of the benefits and risks of SGLT2 inhibitors, including the clinical risk of volume changes in these patients, is warranted. Here, SLC5A2 is linked to type 2 diabetes mellitus.