GH1 and Renal insufficiency: Saizen® (r-hGH, Merck KGaA, Darmstadt, Germany) is a formulation of r-hGH that is marketed for the long-term treatment of children and adolescents with growth failure due to inadequate secretion of endogenous GH, Turner syndrome, renal failure, and growth disturbance in short children born small for gestational age (SGA).