Although a definitive link to BE or EAC has not been established, miR-181b, shown to increase tumor metastasis in a mouse model of non-small cell lung carcinoma (NSCLC), is upregulated in both metastatic human NSCLC and breast cancer and is regulated by CDX2 [87, 88]. The gene discussed is CDX2; the disease is non-small cell lung carcinoma.