Therefore, overexpressed FOXC1 was found to not only aggravate the malignant development of HCC by favouring the EMT and MIV generation [26, 27, 57, 58], but also transactivate genes related to angiogenesis and metastasis, CXCR2 and CCL2, through the IL-8-regulated PI3K/Akt/HIF-α inflammatory signalling pathway. This evidence concerns the gene CXCR2 and hepatocellular carcinoma.