The overexpression of FOXC1 found in Hodgkin's lymphoma was linked to abnormalities in the MSX1 and IPO7 regulation of ZHX2, a gene responsible for tumour suppression; elevated FOXC1 levels interfere with ZHX2 moderation of B-cell differentiation and apoptosis, leading to highly aberrant cell growth that may exacerbate HL lethality [96–98]. The gene discussed is IPO7; the disease is Hodgkins lymphoma.