In HCC specifically, a mutation in the HIF1-α binding sites in the sequence between nt-960 and -635 in the FOXC1 promoter region of HCC cells leads to reduced FOXC1 promoter activity due to decreased IL8-mediated binding of HIF1-α to the FOXC1 promoter [27]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.