The transactivation of genes CXCR2 and CCL2 – which are correlated with tumour angiogenesis and metastasis as well as macrophage infiltration and breast metastasis promotion respectively [27, 78] – with upregulated FOXC1 also plays a role in inflammation-based HCC metastasis [27], indicating that there are many pathways through which FOXC1 influences HCC metastatic potential. The gene discussed is CCL2; the disease is hepatocellular carcinoma.