CARD11 and diffuse large B-cell lymphoma: Elevated CARD11 activity drives the activation of c-Jun and JunB in DLBCL [118, 128] – the constant activation of CARD11 leads to decreased ubiquitination and degradation of c-Jun in human DLBCL cell lines, suggesting that CARD11 is responsible for the stabilization and accumulation of c-Jun [119].