FOXC1 and hepatocellular carcinoma: Furthermore, the expression of FOXC1 was found to be elevated after the eighth day of a 14-day treatment of Huh7 (non-metastatic HCC cell line) cells with TGF-β1 and found that FOXC1 knockdown has no effect on TGF-β isomer expression [58], providing evidence that FOXC1 may operate downstream from TGF-β1.