In a pooled analysis of eight case-control studies of NHL, single nucleotide polymorphisms (SNPs) in tumour necrosis factor (TNF) and interleukin-10 (IL-10) genes –which were responsible for encoding key cytokines in inflammatory response and immune balance – were associated with a risk of NHL, particularly in diffuse large B-cell lymphoma [93, 94]. The gene discussed is IL10; the disease is non-Hodgkin lymphoma.