However, ATE [RR 1.87, 95% CI (0.56, 6.28), P = 0.313], VTE [RR 0.57, 95% CI (0.31, 1.15), P = 0.125], GI perforation [RR 3.16, 95% CI (0.61, 16.45), P = 0.172], renal failure [RR 1.44, 95% CI (0.44, 4.76), P = 0.546], cardiac failure [RR 1.01, 95% CI (0.14, 7.10), P = 0.995], and infusion-related reaction [RR 5.03, 95% CI (0.24, 104.38), P = 0.296] were not reported in the VEGFR-TKI subgroup. Here, KDR is linked to Renal insufficiency.