We also found that hypertension, proteinuria [RR 4.50, 95% CI (1.20, 16.83), P = 0.026] and hand-foot syndrome [RR 16.21, 95% CI (3.77, 69.67), P < 0.001] were significantly increased in patients treated with targeting VEGFR drugs. Here, KDR is linked to hypertensive disorder.