The pooled analysis (AESIs occurred ≥ 2 trials) showed that the risk of hypertension [RR 4.68, 95% CI (2.68, 8.17), P < 0.001, I2< 0.1] in the VEGFR-Ab subgroup was lower than that of the VEGFR-TKI subgroup [RR 8.49, 95% CI (2.92, 24.73), P < 0.001, I2< 0.1], and the risk of proteinuria [RR 3.96, 95% CI (0.46, 34.10), P = 0.211, I2< 0.1] in both the VEGFR-Ab and VEGFR-TKI subgroups [RR 4.27, 95% CI (0.74, 24.49), P = 0.104, I2< 0.1]was not significantly higher than that of the control arm. The gene discussed is KDR; the disease is Hypertension.