HSPB1 and neoplasm: However, a multivariate analysis adjusting for HSP27 expression and multiple clinicopathological factors showed that HSP27 expression was not predictive of tumor recurrence (p = 0.094, 95% confidence interval 0.881–5.024) or progression (p = 0.144, 95% confidence interval 0.720–9.516) (Table 2).