For example, OGX-427 (Apatorsen, OncoGenex, Vancouver, BC, Canada), a sequence of second-generation antisense oligonucleotides (ASO) generated using a 2′-O-(2-methoxy) ethyl (2′-MOE) backbone and targeting HSP27 mRNA, was studied in various cancers. The gene discussed is HSPB1; the disease is cancer.