Therefore, it is not surprising that our bioinformatic analysis suggested significant possible interactions between IL-8, VEGFA, CFH and ARMS2. Thus, the involvement of CFH, ARMS2, IL-8 and VEGFA in the inflammatory, angiogenic and tissue homoeostasis pathways fits perfectly with the clinical phenotype displayed by patients affected with exudative AMD. This evidence concerns the gene ARMS2 and age-related macular degeneration.