COL8A1 and age-related macular degeneration: Moreover, the multivariate logistic regression analysis reported that CFH and ARMS2 accounted for 20% of the overall genetic susceptibility to AMD, while the remaining 3% was attributable to IL-8, TIMP3, SLC16A8, VEGFA and COL8A1. Next, we evaluated the distribution of the number of risk alleles between cases and controls.