Therefore, it is not surprising that our bioinformatic analysis suggested significant possible interactions between IL-8, VEGFA, CFH and ARMS2. Thus, the involvement of CFH, ARMS2, IL-8 and VEGFA in the inflammatory, angiogenic and tissue homoeostasis pathways fits perfectly with the clinical phenotype displayed by patients affected with exudative AMD. Here, CXCL8 is linked to age-related macular degeneration.