COL8A1 and age-related macular degeneration: It is important to note that this estimate accounted for all of the associated genes except for RAD51B. Thus, RAD51B can be considered a very low risk factor for AMD, and it actually loses its significance when taken together with more strongly associated genes (CFH, ARMS2, IL-8, TIMP3, SLC16A8, VEGFA and COL8A1).