Although the exact role of COX7A1 in the diverse metabolic pathways regulating malignancy is not yet clear, recent research reported by Mishra demonstrating that COX7A1 overexpression in the cancer cell line, A549, can induce apoptosis via an intrinsic mechanism (Caspase 9, 3 activation) [50] supports its potential role as a tumor suppressor. Here, CASP9 is linked to cancer.