T-lymphokine-activated killer cell-originated protein kinase (TOPK) is a MAPKK-like serine/threonine protein kinase extensively expressed in various types of cancer, such as colorectal cancer [3], lymphoma [4], melanoma [5], breast cancer [6], lung cancer [7], and cholangiocarcinoma [8]. The gene discussed is PBK; the disease is cholangiocarcinoma.