PBK and central nervous system cancer: Log-rank test showed that glioma patients with high levels of TOPK have poor survival outcome compared with those with low levels of TOPK in HGG or LGG (hazard ratio = 0.2995; 95% CI, 0.1262 to 0.7108; P = 0.0063 and hazard ratio = 0.1509; 95% CI, 0.05928 to 0.3842; P < 0.0001, respectively).