AKT1 and lung carcinoma: We found that NDV/FMW triggered autophagy in paclitaxel-resistant A549 lung cancer cells via dampening the class I PI3K/Akt/mTOR/p70S6K pathway whereas it attenuated the autophagic process in cisplatin-resistant A549 cells through the activation of the negative regulatory pathway (Jiang et al., 2014).