ART4 and cancer: VHSV Gs induce an autophagic antiviral program in vertebrate cell lines. Both wild-type or UV-inactivated virus activates autophagy in DrosophilaS2 cells. VSV infection induces autophagy both in primary cells and in adult flies and in human cancer cells. Autophagy is immediately initiated via VSV infection, probably through the surface glycoprotein VSV G; therefore, initiation does not need viral replication. Induces autophagy Glycoprotein, rather than viral replication, activates the autophagy pathway