Autophagy is required for memory CD8+ T cell formation during an acute viral infection, autophagy in virus-specific CD8+ T cells is essential for cell survival and controlling a chronic viral infection. Chaperone-mediated autophagy activity of BAG3 portrays a particular host defense technique to thwart the capability of VP40 in encouraging efficient egress and spread of virus particles. Here, BAG3 is linked to viral infectious disease.