IFNA1 and infection: Autophagy inhibited RVFV replication and infection. SFTSV NSs inhibited IFN responses independent of Atg7. Induction of autophagosome formation promoted virus replication; inhibition of the host autophagy machinery impedes viral replication. Autophagic clearance of Sin Nombre Hantavirus glycoprotein Gn encourages viral replication.