Autophagy inhibited RVFV replication and infection. SFTSV NSs inhibited IFN responses independent of Atg7. Induction of autophagosome formation promoted virus replication; inhibition of the host autophagy machinery impedes viral replication. Autophagic clearance of Sin Nombre Hantavirus glycoprotein Gn encourages viral replication. This evidence concerns the gene ART4 and infection.