RIGI and infection: Jounai et al. (2007) reported that the overexpression of a mutant of RIG-1 prompted the initiation of NF-κB and IFN-β, which was subdued via the Atg5-Atg12 complex. Interestingly, this suppression appeared to be reliant on the infection with VSV and was documented to prompt a conformational alteration in RIG-1 (Jounai et al., 2007), suggesting that Atgs activated by VSV could modulate RIG-1.