Among the virulence, the heat-stable staphylococcal enterotoxins B (SEB) are the most effective cause of food-borne illness, as it cause infection nanogram levels, can cross gastro-intestinal barrier and easy to aerosolize which implies to use as potent biological weapon (Balaban and Rasooly, 2000; Mudili et al., 2015). The gene discussed is SETBP1; the disease is infection.