ETV1 and Familial prostate cancer: In some prostate cancer cases, a translocation of the HERV-K_22q11.23 5′-LTR-UTR sequence upstream of the transcription factor ETS translocation variant 1 (ETV1) has been described, which results in the enhanced expression of the ETV1 oncogene promoting cancerogenesis (Tomlins et al., 2007).