A review of over 300 case–control and cohort studied used final height as an indication of GH–IGF-1 action and found that individuals over 175 cm have a 20% higher chance of developing prostate cancer, a 22 and 20–60% higher chance of breast and colorectal cancers, respectively, when compared with individuals below 160 cm (278, 279). The gene discussed is IGF1; the disease is Familial prostate cancer.