Greater than 90% reduction in circulating insulin-like growth factor-1 (IGF-1), however no effect on total body or bone growth. Increased IGF-1 mRNA in skeletal muscle. Liver steatosis, insulin resistance, glucose intolerance, increased circulating free fatty acids, leptin, resistin, and adiponectin (257–260). This evidence concerns the gene IGF1 and Glucose intolerance.