The mutations or genetic polymorphisms of EGFR may result in primary resistance on EGFR-TKIs, and gene copy alterations in pathways frequently induce acquired resistance, such as MET is considered one of the more common causes of acquired resistance in EGFR-mutant NSCLC (Rotow and Bivona, 2017). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.