Impaired GR function and an MR/GR imbalance alters the negative feedback regulation within the LHPA, followed by the dysregulation and hypercortisolemia that is associated with decreased postsynaptic 5-HT1A receptor activity, thereby resulting in serotoninergic dysfunction (Lesch et al., 1990). This evidence concerns the gene NR3C1 and adrenal gland hyperfunction.