Previous studies demonstrate that Netrin-1 facilitates angiogenesis and long-term neurological recovery (Lu et al., 2011, 2012), decreases the infarct size (Ding et al., 2014; Yang et al., 2017), improves spatial memory and synaptic plasticity (Bayat et al., 2012), and promotes anti-apoptosis after stroke. The gene discussed is NTN1; the disease is Stroke.