WB indicated a significant impact of MALAT1 inhibition and/or overexpression on the protein levels of NRF1 and NRF2; importantly, downregulation of NRF1, NRF2, and PSMβ5 proteins was also confirmed in primary CD138+ MM cells treated ex vivo with g#5 (Fig. 3a and Fig. S6d). This evidence concerns the gene SDC1 and Miyoshi myopathy.