In AMO-BZB cells, transfection of KEAP1-targeting siRNAs upregulated both NRF1 and NRF2 proteins, as well as PSMβ5 subunit (Supplementary Fig. S8), thus supporting a negative role of KEAP1 on NRF1 and NRF2 stability in MM cells. Here, NRF1 is linked to Miyoshi myopathy.