PNPLA3 and metabolic dysfunction-associated steatotic liver disease: When these 4 NAFLD-associated variants were tested together, they explained, overall, about 7% of the genetic risk of NAFLD and the rs738409 in PNPLA3 ranked as the strongest predictor (OR = 3.12, 95% CI, 1.8-5.5, P < 0.001) when adjusted for conventional risk factors (Table 3).