In particular, Speliotes E.K. et al. 14 reported that variants in Protein Phosphatase 1 Regulatory Subunit 3B (PPP1R3B), Glucokinase Regulatory Protein (GCKR), Neurocan (NCAN) and Lysophospholipase Like 1 (LYPLAL1) genes were associated to the presence of NAFLD. This evidence concerns the gene NCAN and metabolic dysfunction-associated steatotic liver disease.