PNPLA3 and metabolic dysfunction-associated steatotic liver disease: When considered on individual basis, PNPLA3 variant ranked as the strongest genetic predictor of NAFLD followed by GCKR. In contrast, a weaker association was detected for TM6SF2 and MBOAT7. These observations could be partially explained by the low frequency of TM6SF2 risk allele as compared to PNPLA3 risk allele27.