PNPLA3 and metabolic dysfunction-associated steatotic liver disease: After adjustment for covariates such as age, gender, body mass index (BMI), HOMAIR and TG, a dominant model of inheritance best explained the association with NAFLD of rs738409 C/G PNPLA3 (OR = 3.2, 95% CI, 1.79-5.59, Padj < 0.001).