Although this observation is not in complete agreement with previous work by Wang et al., indicating unchanged abundance or subcellular distribution of Mdm2 in IAV-infected cells compared with mock-infected cells19, this discrepancy may be explained not only by the differential origin of cellular models (simian/canine versus human) but also by differences in the infection parameters used (viral strains, MOI and replication kinetics). The gene discussed is MDM2; the disease is infection.