To further characterize the impact of infection on Mdm2 expression, we mock-infected or infected A549 cells to reproduce different viral conditions of marked decrease (MOI 4, 4 and 8 hpi) or increase (MOI 0.1, 24 hpi) of Mdm2 RPL compared to mock and measured Mdm2 mRNA levels by RT-qPCR (Fig. 1C). This evidence concerns the gene MDM2 and infection.