TNF and type 2 diabetes mellitus: Multiple samples Canonical Correspondence analysis (CCA) and correlation heat-map analysis were applied to investigate the correlations between intestinal microbiota (markedly changed eight bacteria by XXT) and T2DM related indexes (TC, TG, LDL-C, HDL-C, IL-6, TNF-α, CRP and resistin) (Figs 7 and 8).