Patients with positive intratumoral AGO1 expression had higher incidences of young age (P = 0.039), high serum alpha-fetoprotein (AFP; P = 0.002), HBeAg-positive status (P = 0.049), HBV DNA ≥ 5 × 102 IU/ml (P = 0.043), liver cirrhosis (P = 0.045), and intrahepatic or extrahepatic recurrence (P < 0.001; Table 2). The gene discussed is AFP; the disease is cirrhosis of liver.