GPT and hepatitis A virus infection: However, relapse of viremia (29.3 × 106 copies/mL) developed and she was treated with lamivudine again for no detectable genotypic resistance (insurance coverage policy), but switched to adefovir shortly afterwards because of emergence of rtM204V/rtL180M mutants accompanied by a mild hepatitis flare: alanine transaminase (ALT) 49 U/L.