The QSP model may thus be used to follow, via kinetic and quantitative simulations, key model variables which represent actual biology or can be transformed to give actual biological meanings, including tumor size (expressed as tumor volume over time), levels of DCm, Agsys, dTeff, as well as immuno-suppressive (PD-L1 and ISC) and immuno-activating (IAR) driving functions, under any desired treatment conditions: control, RT and anti-PD-L1 monotherapies, and combination (Fig. 3). The gene discussed is CD274; the disease is neoplasm.