CD274 and neoplasm: To further explore mechanisms underlying variability in the observed responses to treatments, we simulated tumor size dynamics, as well as DCm, Agsys, activated intra-tumor dTeff counts, and PD-L1 expression levels for two extreme cases corresponding to individuals within either the 10th or 90th percentile of SL values (T cell effectiveness in infiltrating tumor tissue following Agsys exposure) of, respectively, 1.77 and 22.63 RU.