EGFR and non-small cell lung carcinoma: Several monoclonal antibody (MAb) therapies have also been approved for first-line treatment of advanced NSCLC, including bevacizumab (approved for non-squamous only), which targets vascular endothelial growth factor (VEGF) [5]; necitumumab (approved for squamous only) [6], which targets EGFR; and most recently, pembrolizumab, which targets the programmed death-1 (PD-1) immune checkpoint receptor on cytotoxic T cells [7].