Regarding the use of gene promoter methylation as CRC biomarker, the best detection performance was disclosed by SEPT9 promoter methylation, followed by MGMT. Remarkably, SEPT9 validity estimates were similar to those of the trademark assays using SEPT9 methylation [12, 35], further confirming its biomarker potential. The gene discussed is SEPTIN9; the disease is colorectal carcinoma.