In agreement with the report by Wu J. et al. that PTX induced significant augmentation of TLR4 expression in melanoma cells [5] and TLR4 supported growth and survival of cancer [22, 25], it was found that MDA-MB-231 BCA and MDA-MB-435 melanoma cells treated with PTX had increased expression of TLR4, which is similar to the finding in MCF-7 BCA cells in recent publications, that 6-phosphofructo-2-kinase, a critical regulator of glycolysis, modulated TLR4 expression after PTX exposure [26]. The gene discussed is TLR4; the disease is cancer.