Menopause seemed to modify the association between insulin and IGF1R expression (p = 0.07) and the difference in IGF1R expression between tumors of insulin and non-insulin users was only observed among premenopausal women with diabetes (OR = 5.10; 95%CI:1.36–19.14; p = 0.02; Fig. 4, Additional file 1: Table S9 and S10). The gene discussed is INS; the disease is diabetes mellitus.