We found no significant heterogeneity between tumor expression of the proteins of interest between diabetes type 1 and type 2 insulin users, except for p-ER (type 1 vs. type 2: OR = 0.28; 95%CI:0.08–0.95; p = 0.04) (Additional file 1: Table S8 and S10), but after adjustment for menopause and BMI this difference was non-significant. The gene discussed is ESR1; the disease is type 1 diabetes mellitus.