MTOR and neoplasm: Additional analyses including the proportion of positively stained tumor cells as a continuous factor (using the ZIB model) gave similar results (data not shown); e.g. in the analyses for p-mTOR, the binary components explained most of the difference (estimate = − 1.21, p = 0.02), while the count component did not add much (estimate = 0.03, p = 0.80).