Any insulin use was significantly associated with higher expression of IGF1R (OR = 2.36; 95%CI:1.02–5.52; p = 0.04) and p-mTOR (OR = 2.35; 95%CI:1.13–4.88; p = 0.02; Fig. 4, Table 2 and Additional file 1: Table S8) in breast tumors. The gene discussed is INS; the disease is breast neoplasm.