Among women with diabetes, insulin use (n = 53) was significantly associated with higher tumor protein expression of IGF1R (OR = 2.36; 95%CI:1.02–5.52; p = 0.04) and p-mTOR (OR = 2.35; 95%CI:1.13–4.88; p = 0.02), especially among women treated with insulin analogues. This evidence concerns the gene INS and diabetes mellitus.