This would explain its ability to activate the microglial cell line however Kieran et al [75] found that K40I failed to activate Akt-1 in NSC34 cells while Peng et al [79] show that ANG H37A activates Akt-1 in a bladder cancer cell line at similar levels to WT ANG. The gene discussed is AKT1; the disease is urinary bladder cancer.