In order to determine whether the cellular uptake of ANG is clathrin mediated, we used two small molecule inhibitors of dynamin—dynasore and Dyngo4a and studied their effect on ANG uptake in (1) the neuroblastoma cell line SH-SY5Y; (2) the hybrid motor neuron cell line VSC4.1 [36]; (3) the astrocytic cell line C8-D1A [35]; (4) the microglial cell line BV2 [37] and (5) mouse primary cortical neurons and astrocytes. The gene discussed is DNM1; the disease is neuroblastoma.