AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: While dysregulation in signaling by the PI3K/AKT/FOXO, Hedgehog, Wnt and Jak/STAT pathways, as well as DNA damage repair regulating pathways, has been putatively involved in CML stem cells insensitivity to treatment, involvement of the NF‐κB signaling, particularly in conjunction with increased activities of SFKs and MEK‐ERK, in the resistance of CML stem cells to TKIs has not been previously identified.