LYN and chronic myelogenous leukemia, BCR-ABL1 positive: This combination previously showed a strong pro‐apoptotic effect on CML cell lines that were resistant to IM due to (i) mutations in Bcr‐Abl1 kinase domain, (ii) overexpression of Bcr‐Abl1, or (iii) overexpression of Lyn (Nguyen et al., 2007).