Our immunohistochemical studies indicated alterations of α‐amylase in AD patients (fewer AMY1A + DS, increased number of AMY1A + HB and AMY2A + astrocytes gathered around Aβ plaques) and to investigate whether these alterations are reflected on a gene level, we analyzed the α‐amylase expression. The gene discussed is AMY2A; the disease is Alzheimer disease.