Tumor angiogenesis, required for malignancy, is under control of miRNAs: miR-221/222 are anti-angiogenic (through the stem cell factor (SCF) and KIT Proto-Oncogene Receptor Tyrosine Kinase (c-Kit) axis), while miR-27b, miR-130a, and miR-126, the last also termed angiomiR, are pro-angiogenic. The gene discussed is KITLG; the disease is neoplasm.