2012; Cervantes‐Rodriguez et al. 2014; Fullston et al. 2015; Huypens et al. 2016). We propose that having a father on a HFD prior to conception contributes to the initial enhancement of skeletal muscle insulin signaling in the HFO, possibly as an attempt to protect against early onset insulin resistance if they are exposed to a HFD, similar to their father. In the current study, the offspring were fed a standard chow and not exposed to a nutritional stress, hence only exposed to the “single‐hit” of having their father exposed to a HFD. The gene discussed is INS; the disease is Insulin resistance.