Although preclinical experience with in situ reconstitution of lymphatic networks using VEGF-C exists for more than 15 years, there is only one ongoing phase I clinical trial using VEGF-C therapy, namely the application of a VEGF-C-expressing adenovirus (AdVEGF-C, see Figure 4), in combination with lymph node transplantation for the treatment of secondary lymphedema after breast cancer surgery. This evidence concerns the gene VEGFC and breast cancer.