DLGAP1, located on chromosome 18p11.31, which is also known as SAP90/PSD‐95‐associated protein (SAPAP) encoding the guanylate kinase‐associated protein (GKAP), was involved in the pathophysiology of several psychiatric disorders, such as obsessive‐compulsive disorder (OCD), schizophrenia (SCZ), major depression disorder (MDD), and Alzheimer's disease (AD; Bertram et al., 2008; Li et al., 2013; Mathias et al., 2016). This evidence concerns the gene DLGAP1 and major depressive disorder.