These include CD4+ Foxp3− T cells that secrete IL‐10, TGF‐β and IL‐35 and are termed Tr1, Th3 and Tr35, respectively.124, 125, 126 In addition, other suppressive cells not belonging to the Th lineage include CD3+ CD4− CD8− double‐negative T cells, Qa‐1‐restricted CD8 Tregs and CD28loCD8+ Tregs.127, 128, 129 While these additional regulatory T‐cell subsets have not been as well studied as the conventional CD4+ Foxp3+ Tregs that are discussed in this review, there is evidence for their protective involvement in renal disease.27, 123, 130, 131, 132. This evidence concerns the gene CD8A and kidney disorder.