TGFB1 and inflammatory bowel disease: For example, private missense mutations in genes encoding components of the IL‐10 receptor (IL10RA or IL10RB) have also been shown to cause a severe, early‐onset form of IBD in consanguineous families due to abrogation of IL‐10 signalling.63 Other anti‐inflammatory cytokines – and genes involved in their signalling pathways – have also been identified within CD‐associated genetic loci, including IL22 (another member of the IL‐10 cytokine family) and SMAD3 and SMAD7, which are important components of TGFβ signalling.