Attenuation of Ras activity in Nf1+/− mouse models using lovastatin [18] or, alternatively, through genetic co-deletion of the Pak1 gene (Nf1+/−, Pak1+/−) [7] rescues the biochemical, electrophysiological and behavioural deficits, including normalisation of social memory and autism-like behavioural phenotypes. Here, PAK1 is linked to autism.