Feinkohl et al. [68] investigated the association between macrovascular disease markers and cognitive decline in 832 diabetic patients by detecting clinical parameters, including cardiovascular event history, carotid intima-media thickness (cIMT), ankle brachial index (ABI), and serum N-terminal probrain natriuretic peptide (NT-proBNP). The gene discussed is NPPB; the disease is Mental deterioration.