Similarly, in the subgroup analysis of DFS by cancer type, we found that an increased ENG expression in tumor microvessel was associated with poor DFS of patients with head and neck squamous cell carcinomas (HR = 5.62, 95% CI 3.16–10.00, P < 0.001) and other cancers (HR = 1.88, 95% CI 1.42–2.50, P < 0.001) (Figure 4C). Here, ENG is linked to head and neck squamous cell carcinoma.