SCD5 and melanoma: Considering the inverse functional correlation between SCD5 and miR-221&222 during melanoma progression [9, 18] and the predicted presence of one conserved binding site for these miRs in the 3′ Untranslated Region (3′UTR) of SCD5 mRNA (http://www.targetscan.com) (Figure 3A), we hypothesized the involvement of these microRNAs (miRs) in SCD5 regulation.