Considering that in melanoma SCD5 plays its main role by converting stearic into oleic acid (OA) and in view of the reported capability of OA to mimic SCD5 functional effects reducing melanoma malignancy [9], we finally evaluated whether the exogenous supplementation of OA could be per se active on EMT-reversion as well as on melanoma differentiation. Here, SCD5 is linked to melanoma.