In fact western blot analysis of proteins extracted from A375M/SCD5 tumor nodules, in addition to Snail Family Transcriptional Repressor 1 (SNAI1/SNAIL) and Twist Family BHLH Transcription Factor (TWIST) reduction and ZEB2 up-regulation, showed the induction of E-cadherin (Figure 6C). This evidence concerns the gene SNAI1 and neoplasm.