Conversely, the degradation time of SCD5 protein, evaluated in the same cell lines up to 18 hours after CHX action, evidenced significantly accelerated protein degradation of SCD5 in the metastatic A375 cell line (half-life ∼90 min), compared with the slow rate in Me1007 primary melanoma (half-life of approximately 12 hours) (Figure 1A, 1B). This evidence concerns the gene SCD5 and melanoma.