Considering the role of RTK/PI3K/mTOR pathway in gliomagenesis as well as the elevated expression profile of genes associated with mitochondrial dysfunction and oxidative stress in DIPG, we hypothesized that targeting mitochondria and RTK/PI3K/mTOR pathway may represent a rational therapeutic strategy against this aggressive pediatric brainstem glioma. This evidence concerns the gene MTOR and diffuse intrinsic pontine glioma.