Only the cytokines GM-CSF, IFN-γ, IL-2, IL-4 and TNF-α were detected at relevant concentrations in the presence of UniCAR CD28/ζ-armed T cells, tumor cells and TM substantiating that cytokine secretion occurs in a strictly TM- dependent- and target-specific manner (Figure 5). This evidence concerns the gene IFNG and neoplasm.