The study of YTH domain family expression indicated that YTHDF1 was overexpressed in CRC portions compared with normal counterparts, while other YTH domain family members, YTHDF2, 3 and YTHDC1, 2, showed little difference between cancer and normal portions in the TCGA database (https://cancergenome.nih.gov). The gene discussed is YTHDF1; the disease is colorectal carcinoma.