SALL1 and acute myeloid leukemia: To examine the effect of SALL1 downregulation on leukemia engraftment in vivo, we traced human AML cell lines engraftment and leukemia progression in irradiated NSG mice injected with MV4-11 or THP1 cells treated with either sh-SALL1 or ctrl-GFP-SALL1, 5 mice in each group, Figure 4D.