PRG4 and cancer: Among the 47 commonly mutated cancer genes shared between mouse and human LUSCs, the frequently mutated ones in human LUSCs include KMT2D (MLL2), MYH1, OBSCN, ZEB2, BRAF, IGF2R, FLT1, HIVEP3, PRG4, ABCA1, ATR, DACH2, ABCB4, DST, and MUC4 (Figure 2).