Among the 47 commonly mutated cancer genes shared between mouse and human LUSCs, the frequently mutated ones in human LUSCs include KMT2D (MLL2), MYH1, OBSCN, ZEB2, BRAF, IGF2R, FLT1, HIVEP3, PRG4, ABCA1, ATR, DACH2, ABCB4, DST, and MUC4 (Figure 2). Here, KMT2D is linked to cancer.