IL2RB and cancer: The most frequent clonal mutations were found in the following cancer genes: Hspa9, Cdk1, Pcdhb15, Ctsll3, Gga1, Igf2r, Il2rb, Dlgap1, Nkain2, and Pyy. HSPA9 (mortalin/GRP75/PBP74), was overexpressed in different tumor types and detected in different subcellular compartments of cancer cells, indicating its functional role in cancer [40, 41].