Some of the most interesting genes up-regulated in the tumors that express neither MYB nor MYBL1 included JUNB, FOXO1, KLF4, VGLL3, and FOSB, all of which encode transcription factors and could be potential ‘drivers’ of this ‘non-MYB’ subgroup of ACC tumors. The gene discussed is FOXO1; the disease is adrenal cortex carcinoma.