In contrast, the genes correlated most closely with MYB or MYBL1 expression included chemokine CXXC4 and the transcription factors SOX4 and EN1. The latter gene, which encodes the engrailed homeobox 1 transcription factor, has been identified previously as an important biomarker in ACC tumors [30]. This evidence concerns the gene MYB and adrenal cortex carcinoma.