MDM4 and obesity due to melanocortin 4 receptor deficiency: Taken together, these data suggest BAT associated genes including lipid oxidative genes were selectively activated in fat tissues in p533KR/3KR/mdmx-/- mice, resulting in increased energy production and fat dissipation, leading to protection against diet-induced obesity and prevention of insulin resistance in p533KR/3KR/mdmx-/- mice.